Fri Mar 14 2025

45 articles - From Friday Mar 07 2025 to Friday Mar 14 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

J Crohns Colitis

Definitions, Diagnosis and Management of Postoperative Recurrence in Crohn's Disease Patients with Permanent Ileostomy - A Systematic Review and Meta-Analysis.

There is a lack of standardized monitoring tools and criteria for diagnosing recurrence in patients with Crohn's disease and permanent ileostomy. The results of this systematic review will form the basis of a global expert recommendation exercise focused on developing management standards and trial endpoints for this condition.

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Pancreatology

Inflammatory markers in predicting survival in pancreatic cancer: A Systematic review and Meta-Analysis.

NLR and PLR effectively predicted PC outcomes and hold potential for evaluating therapeutic responses and identifying candidates for additional treatment strategies in advanced disease.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Both general and central obesity are associated with increased risk of irritable bowel syndrome: a large-scale prospective cohort study.

Further sensitivity analyses and subgroup analyses demonstrated similar results. Both general and central obesity are associated with increased risk of developing IBS, suggesting the importance of obesity management.

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Estimates and projections in the economic impacts of 15 dietary risk factors for 204 countries and territories from 2020 to 2050: a health-augmented macroeconomic modelling study.

Diet low in whole grains (INT $3808 billion) incurred the highest cost, followed by diet high in sodium (INT $2812 billion) and red meat (INT $2337 billion). The global macroeconomic burden attributable to dietary risks was substantial and varied across countries, regions, income groups, disease types, and individual dietary risk factors.

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Greenhouse gas emissions in relation to micronutrient intake and implications of energy intake: A comparative analysis of different modelling approaches.

This study highlights implications of energy intake when assessing the impact of dietary GHGE and demonstrates that the choice of GHGE modelling approach might have important consequences for the results and interpretation. The method of choice for modeling dietary GHGE in relation to micronutrient intake needs to be carefully considered in future studies.

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Individualized nutritional intervention versus routine care for gestational diabetes prevention: A randomized controlled trial.

Among females at risk of GDM, an individualized nutritional intervention based on Chinese dietary guidelines provided before the OGTT did not prevent GDM but helped to manage GWG appropriately and improved pregnancy outcomes. ChiCTR 1900026963 registered on Oct 27, 2019, with initial participant enrollment on May 5, 2020, noted at URL:

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Survival and parenteral nutrition dependence in patients aged 65 and older with short bowel syndrome: a retrospective observational cohort study.

Nearly half of SBS-CIF patients on PS were aged ≥65, with PS dependence and survival rates comparable to younger patients. These findings suggest that age should not be a barrier to PS initiation.

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Inflamm Bowel Dis

Characterization of the Regulatory Landscape in Crohn's Disease Reveals microRNA-Associated Alterations that Shape Anti-TNF Response.

A comprehensive miRNA profiling revealed significant intestinal tissue-specific variability and identified key alterations in the miRNA-mRNA interactome that might be involved in therapeutic response to anti-TNF in CD.

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Evolution of Extraintestinal Manifestations in Patients With Ulcerative Colitis Post-Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis: A Single-Center Retrospective Study.

The EIM rate increases post-IPAA surgery in UC patients, and most preoperative EIMs do not resolve. Awareness of the factors associated with EIMs will enable earlier detection and management for improving patient well-being and quality of life.

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Intestinal Permeability In Vivo in Patients With Inflammatory Bowel Disease: Comparison of Active Disease and Remission.

Intestinal permeability is increased in IBD using validated in vivo assay relative to NHV; increased IP in IBD persists during remission.

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Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography.

Comparable results with white light endoscope and histological examination suggest the clinical potential of the 1310 nm endoscopic OCT system for in vivo assessment of IBD.

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Mechanosensitive Ion Channel PIEZO1 as a Key Regulator of Intestinal Fibrosis in Crohn's Disease.

PIEZO1 plays a pivotal role in the regulation of intestinal fibrosis by maintaining the levels of HIF-1α, thereby promoting EMT. Therapeutic strategies targeting PIEZO1 could be used to prevent intestinal fibrosis in CD patients.

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Prevalence of Irritable Bowel Syndrome Based on Rome IV Criteria in Patients in Biochemical and Endoscopic Remission From Newly Diagnosed Inflammatory Bowel Disease: One- and Three-Year Results (the IBSEN III Cohort).

The prevalence of IBS among patients in remission from IBD was approximately twice as common as that in the Norwegian population. Irritable bowel syndrome was independently associated with substantial fatigue, female sex, and reduced HRQoL.

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Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn's Disease Commencing Biological Therapy: The Motility Study.

No factor predicted patient QoL. Motility MRI remains a marker of disease activity at given timepoints.

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Superb Microvascular Imaging Is Superior to Doppler Imaging in Ruling Out Ulcerative Colitis Disease Activity.

IUS is a highly precise noninvasive diagnostic tool to monitor disease activity in UC, in particular for predicting endoscopic remission. Assessing the SMI signals in the bowel wall of patients with IBD seems a promising tool to simplify IUS diagnostics in IBD that warrants further research.

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The Role of Human Leukocyte Antigen Alleles and Maternal Microchimerism in Very-Early-Onset Ulcerative Colitis in Japanese Children.

VEO-UC seems to share genetic traits with adult UC, such as an association with HLA-B52 and HLA-DR15, and is also affected by maternal immune contributions, as shown by the presence of MMc in the affected tissues. These findings highlight the complex interaction between genetic and immunological factors in the pathogenesis of VEO-UC and underscore the need for further research to develop targeted therapeutic strategies that address these mechanisms.

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J Crohns Colitis

Artificial intelligence-assisted approach to assessing bowel wall thickness in pediatric inflammatory bowel disease using intestinal ultrasound images.

This study demonstrates an AI approach to automate the analysis of pediatric IBD IUS images, providing a reliable tool for early detection, precise characterization, and monitoring of the disease.

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Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease.

Our study reveals that BFT produced by ETBF leads to a reduction of m6A modifications by reducing METTL3 transcription and promotes ITGA5 expression in inflammatory macrophages. These findings provide new insights into the modulation of human m6A epitranscriptome in macrophages by gut microbiota and its significance in inflammatory bowel disease progression.

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Environmental Risk Factors of Inflammatory Bowel Disease: Towards a Strategy of Preventative Health.

Despite the promise shown by observational data, interventional or randomized controlled studies evaluating the efficacy of modifying environmental risk factors remain limited and mostly focus on dietary intervention. This review aims to inform the design of higher-quality interventional and randomized controlled studies for disease prevention while providing actionable guidance to healthcare providers on reducing the risk of developing IBD through environmental modifications.

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Epithelial Genetic Muscarinic Receptor 3 Ablation Induces Sex-Specific Modulation of Colonic Intestinal Progenitor Cells and Response to Intestinal Injury.

Our data reveal sex differences in the modulation of intestinal, colonic epithelial cells by cholinergic, muscarinic signaling and highlight the potential for therapeutic strategies targeting cholinergic receptor signaling in colonic inflammatory diseases.

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Higher Dietary Glycemic Index, but not Glycemic Load, is Associated with Increased Risk of Ulcerative Colitis: A Prospective Cohort Study.

A higher dietary glycemic index, but not glycemic load, is associated with an increased risk of UC, underscoring the importance of considering glycemic index in dietary recommendations for UC prevention.

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Multimodal Metagenomic Analysis Reveals Microbial InDels as Superior Biomarkers for Pediatric Crohn's Disease.

Our study provided a comprehensive landscape of microbial alterations in pediatric CD and introduced a highly effective diagnostic model rooted in microbial InDels, which contributes to the development of the non-invasive diagnostic tools and targeted therapies.

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Novel Outcomes in Inflammatory Bowel Disease.

This review analyses published clinical studies involving patients with UC and CD treated with biologics or small molecule therapies. It highlights novel IBD endpoints employed in published clinical trials and discusses their likely value for assessing disease activity and disease modification, and as predictors of reduced risk of complications and morbidities.

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Liver Transpl

A snapshot of challenges and opportunities faced by the scientific workforce in liver transplantation - a survey of the International Liver Transplantation Society (ILTS).

Looking ahead, advancing technologies, machine learning/artificial intelligence, multi-omics, xenotransplantation, and machine perfusion were highlighted as areas with potential to significantly shift the paradigm in the near future. Our survey captured insights from B&TR scientists within the ILTS, identifying both challenges and opportunities for future developments and aiding in the strategic direction of the society's initiatives.

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Failure to rescue in acute liver failure: A multicenter cohort study.

In patients with ALF, the concept of failure to rescue highlights the need to improve prevention, early detection, and timely management of medical complications developing early in the hospital stay.

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Pediatric living donor liver transplantation for small infants with biliary atresia using interposition portal vein grafts, multi-center cohort study.

Portal inflow reconstruction using interposition grafts during LDLT for biliary atresia achieves favorable long-term patency and patient and graft survival outcomes. This approach has the potential to mitigate morbidity and mortality in pediatric BA patients undergoing LDLT. Longer cold-stored venous allografts are associated with a higher risk of PV complications after LDLT.

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Proceedings of the 29th Annual Congress of the International Liver Transplantation Society.

In addition to a robust scientific program, the congress also hosted a hands-on cadaveric robotic liver surgery course, a machine perfusion workshop, and a transesophageal echocardiography course. In this report, the ILTS Vanguard and Basic Sciences Committees present a summary of the congress proceedings.

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To Err Is Robot - an analysis of complications following robotic donor hepatectomy.

Although RDH appears to be safe, critical complications can occur in a minority of cases. Safety lies in flattening the learning curve.

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Pancreatology

Circulating cyclophilin A levels elevate in animal models and can predict mortality in patients with acute pancreatitis.

Circulating CypA levels are significantly increased in mouse CER-AP and hamster HTG-AP models. We have identified a novel association of raised plasma CypA levels with severity of HTG-AP and confirmed its significant prognostic ability to predict mortality in AP patients.

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Class V pancreatic fluid cytology is associated with intrapancreatic recurrence of intraductal papillary mucinous neoplasms.

In multivariate analysis, class V pancreatic fluid cytology was significantly associated with developing intrapancreatic recurrence (P = 0.0149, OR 22.7, 95 % CI 1.83-279). Preoperative class V pancreatic fluid cytology is associated with intra-pancreatic recurrence after resection of IPMN.

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Early response evaluation using CT and CA 19-9 in patients with pancreatic cancer of all stages undergoing first-line FOLFIRINOX treatment.

Our combined evaluation of CT and CA 19-9 responses successfully stratified the survival of patients with PDAC treated with FOLFIRINOX, irrespective of disease stage.

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Tocilizumab for Painful Chronic Pancreatitis (TOPAC trial): Protocol for a phase 2 randomized, placebo-controlled, double-blind, investigator-initiated trial.

This placebo-controlled clinical trial aims to study the potential clinical benefits of blocking IL-6 signalling in painful CP.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Is it time to take a closer look at ultraprocessed foods?

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Inflamm Bowel Dis

A Comprehensive Perspective on Primary Sclerosing Cholangitis Research: Multidimensional Analysis From Literature Review to Patient Quality of Life.

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Altered Bile Acids and Pouch Microbiota Composition in Patients With Chronic Pouchitis.

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Improving Brain-Gut Studies in Crohn's Disease: Methodological Considerations.

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Opioids Intertwined With Psychology: Hidden Effects in the Treatment of Patients With IBD.

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Optimizing Hepatitis B Vaccination Strategies for Patients With Inflammatory Bowel Disease.

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Total Proctocolectomy Versus Subtotal/Total Colectomy for Neoplasia in Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Utilization of Super-Resolution Contrast-Enhanced Ultrasonography in Diagnosing Intestinal Behçet's Disease With Enterovesical Fistula.

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Liver Transpl

Normothermic liver perfusion: Is the juice worth the squeeze?

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Policy Corner: transplant oncology, colorectal liver metastases MELD non-standard exception.

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The impact of alcohol-associated liver disease on famous athletes who received Liver Transplants.

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Letters&Replies

Letters to the editors and authors’ replies

Inflamm Bowel Dis

Reply: Opioids Intertwined With Psychology: Hidden Effects in the Treatment of Patients With IBD.

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Pancreatology

The duodenum-preserving head resections for chronic pancreatitis: Beger, Livocado and Pottakkat.

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